Research in the Thermal and Vascular Physiology Laboratory focuses on neural control of the cardiovascular system and how different stressors influence that control in healthy, diseased, and injured individuals, such as:
- Identifying the consequences of severe burn injuries and subsequent skin grafting on the ability of the burn survivor to regulate internal temperature and cardiovascular function.
- Understanding the consequences of aging on cardiovascular stress during simulated heat waves.
- Exploring cooling modalities to attenuate thermal and cardiovascular stress.
- Understanding how analgesics used on the battlefield affect autonomic control of blood pressure during hemorrhage.
- Dr. Crandall’s research interests revolve around neural control of the cardiovascular system, with emphasis on how thermal stress modifies this control.
- Research areas range from integrative thermoregulatory studies in healthy and unique populations (e.g., skin graft patients) to mechanistic studies on the skin microcirculation.
Clinical applications of this work include:
- Improved blood pressure control during hemorrhage (particularly in heat stressed individuals such as soldiers, construction workers, etc.).
- Improved temperature regulatory capacity injured/diseased individuals (e.g., skin graft patients, congestive heart failure, etc.
- Effects of burn injuries on thermoregulatory and cardiovascular responses in soldiers.
- Cooling modalities to attenuate thermoregulatory and cardiovascular stress in burn survivors and the elderly.
- Mechanisms by which heat stress compromises blood pressure control during hemorrhage.
- Effects of battlefield analgesics on tolerance to hemorrhage.
Exercise Core Temperature Response
Cramer, M.N., G. Moralez, M. Huang, K. Kouda, P.Y.S. Poh, C.G. Crandall. Exercise Core Temperature Response with a Simulated Burn Injury: Effect of Body Size. Med Sci Sports Exerc 52:705-711. 2020. PMCID: PMC7024043.
Exercise Thermoregulation with a SimulatedCramer, M.N., G. Moralez, M. Huang, K. Kouda, P.Y.S. Poh, C.G. Crandall. Exercise Thermoregulation with a Simulated Burn Injury: Impact of Air Temperature. Med Sci Sports Exerc 52:712-719, 2020. PMCID: PMC7024026
Progressive exercise trainingRomero, S.A., G. Moralez, M.F. Jaffrey, M. Huang, M.N. Cramer, N. Romain, K. Kouda, R.G. Haller, C.G. Crandall. Progressive exercise training improves maximal aerobic capacity in individuals with well-healed burn injuries. Am J Physiol Reg Comp Physiol 317:R563-R570, 2019. PMCID: PMC6842906.
Cardiac structure and function in well-healed burn survivorsSamuel, T.J., M.D. Nelson, A. Nasirian, M. Jaffrey, G. Moralez, S.A. Romero, M.N. Cramer, M. Huang, K. Kouda, S. Sarma, C.G. Crandall. Cardiac structure and function in well-healed burn survivors. J Burn Care Res 40:235-241, 2019. PMCID: PMC6295495.
Hemostatic responsesBorgman, M.A., M. Zaar, J.K. Aden, Z.J. Schlader, D. Gagnon, E. Rivas, J. Kern, V.A. Convertino, A.P Cap, C.G. Crandall. Hemostatic responses to exercise, dehydration, and simulated bleeding in heat-stress humans. Am J Physiol Reg Comp Physiol316:R145-156, 2019. PMCID: PMC6397353.
Tolerance to a haemorrhagic challengeHuang, Mu, R.M. Brothers, M.S. Ganio, R.A.I. Lucas, M.N. Cramer, G. Moralez, V.A. Convertino, C.G. Crandall. Tolerance to a haemorrhagic challenge during heat stress is improved with inspiratory resistance breathing. Exp Physiol 103:1243-1250, 2018. PMCID:PMC6119106
Folic acid supplementationGagnon, D., S.A. Romero, M.N. Cramer, K. Kouda, P.Y.S. Poh, H. Ngo, O. Jay, C.G. Crandall. Folic acid supplementation does not attenuate thermoregulatory or cardiovascular strain of older adults exposed to extreme heat and humidity. Exp Physiol 103:1123-1131, 2018. PMCID: PMC6105515.
Age Modulates Physiological Responses duringGagnon, D., S.A. Romero, M.N. Cramer, K. Kouda, P.Y. Poh, O. Jay, C.G. Crandall. Age Modulates Physiological Responses during Fan Use under Extreme Heat and Humidity. Med Sci Sports Exerc 49:2333-2342, 2017. PMCID: PMC5645224.
Volume loading augments cutaneous vasodilatation and cardiac outputGagnon, D. S.A. Romero, H Ngo, S. Sarma, W. Cornwell, P.Y.S. Poh, D. Stoller, B.D Levine, C.G. Crandall. Volume loading augments cutaneous vasodilatation and cardiac output of heat stressed older adults. J Physiol 595:6489-6498, 2017. PMCID: PMC5638885
Cardiac and thermal strainGagnon, D., S.A. Romero, M.N. Cramer, O. Jay, C.G. Crandall. Cardiac and thermal strain of elderly adults exposed to extreme heat and humidity with and without electric fan use. JAMA 316: 989-991, 2016. PMCID: PMC5161409
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